JACS Cover design
A mitochondria-targeting, defect-engineered AFCT nanozyme was elaborately designed as a tumor microenvironment (TME)-activatable phototheranostic agent to achieve remarkable antitumor therapy via electron transport chain (ETC) interference and synergistic adjuvant therapy. In response to the dual stimuli of H2O2 and mild acidity, the therapeutic functions can be specifically activated.
