The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Here you can see a recent cryoEM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin (PDB code: 8U18)
hashtag#molecularart ... hashtag#thrombopoietin ... hashtag#receptor ... hashtag#domain ... hashtag#cryoem
Structure rendered with hashtag#proteinimager and depicted with hashtag#corelphotopaint
Here you can see a recent cryoEM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin (PDB code: 8U18)
hashtag#molecularart ... hashtag#thrombopoietin ... hashtag#receptor ... hashtag#domain ... hashtag#cryoem
Structure rendered with hashtag#proteinimager and depicted with hashtag#corelphotopaint
