Coxsackieviruses are a few related enteroviruses that belong to the Picornaviridae family of nonenveloped, linear, positive-sense single-stranded RNA viruses, as well as its genus Enterovirus, which also includes poliovirus and echovirus. Enteroviruses are among the most common and important human pathogens, and ordinarily its members are transmitted by the fecal-oral route. Coxsackieviruses share many characteristics with poliovirus. With control of poliovirus infections in much of the world, more attention has been focused on understanding the nonpolio enteroviruses such as coxsackievirus. Coxsackieviruses are among the leading causes of aseptic meningitis (the other usual suspects being echovirus and mumps virus). The coxsackieviruses were discovered in 1948–49 by Gilbert Dalldorf, a scientist working at the New York State Department of Health in Albany, New York. The discovery of the coxsackieviruses yielded further evidence that viruses can sometimes interfere with each other's growth and replication within a host animal. Other researchers found this interference can be mediated by a substance produced by the host animal, a protein now known as interferon. Interferon has since become prominent in the treatment of a variety of cancers and infectious diseases. Here you can see a recent full structure of Coxsackievirus A16 in complex with a neutralizing antibody determined by cryoEM (PDB code: 7YMS)
#molecularart ... #immolecular ... #virus ... #coxsackievirus ... #antibody ... #cryoem
Structure rendered with @proteinimaging and represented with @corelphotopaint
#molecularart ... #immolecular ... #virus ... #coxsackievirus ... #antibody ... #cryoem
Structure rendered with @proteinimaging and represented with @corelphotopaint
