Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. Here you can see a CryoEM structure of the 20S subunit of the yeast proteasome. This study was performed to check the activity of proteasome inhibitors designed as anticancer drugs (PDB code: 6ZP6)
#molecularart ... #immolecular ... #proteasome ... #inhibitor ... #CryoEM ... #20Sunit ... #yeast ... Rendered with @proteinimaging and finished with @corelphotopaint
#molecularart ... #immolecular ... #proteasome ... #inhibitor ... #CryoEM ... #20Sunit ... #yeast ... Rendered with @proteinimaging and finished with @corelphotopaint
