Tuberculosis, caused by Mycobacterium tuberculosis, responsible for ∼1.5 million fatalities in 2018, is the deadliest infectious disease. Global spread of multidrug resistant strains is a public health threat, requiring new treatments. Aminoacyl-tRNA synthetases are plausible candidates as potential drug targets, because they play an essential role in translating the DNA code into protein sequence by attaching a specific amino acid to their cognate tRNAs. Here you have a very recent CryEM structure of M. tuberculosis Phe-tRNA synthetase complexed with an unmodified tRNAPhe transcript and either L-Phe or a nonhydrolyzable phenylalanine adenylate analog (PDB code: 7KAB)
#molecularart ... #immolecular ... #tuberculosis ... #complex ... #tRNAsynthase ... Rendered with @proteinimaging and polished with @corelphotopaint.
#molecularart ... #immolecular ... #tuberculosis ... #complex ... #tRNAsynthase ... Rendered with @proteinimaging and polished with @corelphotopaint.
